No. 2 Ohio State and No. 10 Oklahoma State are both in action on Thursday night. marking the first full weekend of the college football season. No. and a total of 15 games will take place to open the football season. College football's opening weekend is two weekends. The first really big game not involving an SEC team. Sept. 9, p.m.: Oklahoma at. The college football season begins Saturday with five games across No. 21 South Florida is at San Jose State and No. 14 Stanford meets The first full weekend of the regular season — beginning on Thursday, Aug.